SYNTHESIS AND ANALGESIC EVALUATION OF SOME 1,1-DISUBSTITUTED CARBOXY-4-PHENYL-L,2,3,4-TETRAHYDRO-BETA-CARBOLINE DERIVATIVES

Authors
NAGY T JEANNIN L SAPI J LARONZE JY RENARD P PFEIFFER B BIZOTESPIARD JG
Citation
T. Nagy et al., SYNTHESIS AND ANALGESIC EVALUATION OF SOME 1,1-DISUBSTITUTED CARBOXY-4-PHENYL-L,2,3,4-TETRAHYDRO-BETA-CARBOLINE DERIVATIVES, European journal of medicinal chemistry, 30(7-8), 1995, pp. 575-586
Citations number
25
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
30
Issue
7-8
Year of publication
1995
Pages
575 - 586
Database
ISI
SICI code
0223-5234(1995)30:7-8<575:SAAEOS>2.0.ZU;2-T
Abstract
New 4-phenyl-1,2,3,4-tetrahydro-beta-carbolines were synthesized from beta-phenyltryptophan ester. They were evaluated in induced pain on ro dents. Amide 17b proved to be the most powerful in the series. Several compounds display significative antiinflammatory properties.