A NEW PUTATIVE 5-HT1A RECEPTOR ANTAGONIST OF THE 1-ARYLPIPERAZINE CLASS OF LIGANDS

Authors
CHOJNACKAWOJCIK E KLODZINSKA A DRABCZYNSKA A PAWLOWSKI M CHARAKCHIEVAMINOL S CHLON G GORCZYCA M
Citation
E. Chojnackawojcik et al., A NEW PUTATIVE 5-HT1A RECEPTOR ANTAGONIST OF THE 1-ARYLPIPERAZINE CLASS OF LIGANDS, European journal of medicinal chemistry, 30(7-8), 1995, pp. 587-592
Citations number
25
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
30
Issue
7-8
Year of publication
1995
Pages
587 - 592
Database
ISI
SICI code
0223-5234(1995)30:7-8<587:ANP5RA>2.0.ZU;2-T
Abstract
5-HT1A and 5-HT2A receptor affinities of several omega-alkyl-1-arylpip erazines containing a terminal pyrimidopurine or 1,3-diazepinopurine r ing system are reported. Several behavioral models demonstrated that 2 ,4,8-trioxo-1,3,9-trihydropyrimidino[2,1-f]purine 8 and its analogs 5 and 6 may be classified as 5-HT1A postsynaptic antagonists, whereas 7, 9 and 10 are partial agonists of 5-HT1A receptors.