SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 2-SUBSTITUTED 5-(1,2-DIARYLETHYL)-4,6-DICHLOROPYRIMIDINE DERIVATIVES

A series of 5-(1,2-diarylethyl)-2,4,6-trichloropyrimidines and 2-amino - and zinyl)-5-(1,2-diarylethyl)-4,6-dichloropyrimidines were synthesi zed via organozinc reagents. These new pyrimidine derivatives were tes ted against human bacterial flora. Biological tests showed that rophen yl)-2-phenylethyl]-2,4,6-trichloropyrimidine is very active against a wide range of bacterial flora of the axilla and foot, while 2-amino an d 2-(1-piperazinyl)-4,6- dichloropyrimidine derivatives display a grea t selectivity against Corynebacterium xerosis and Arcanobacterium haem olyticum of the human axilla.