Rapid method for analysis of nicotine and nicotine-related substances in chewing gum formulations

Authors
Sellergren, B Zander, A Renner, T Swietlow, A
Citation
B. Sellergren et al., Rapid method for analysis of nicotine and nicotine-related substances in chewing gum formulations, J CHROMAT A, 829(1-2), 1998, pp. 143-152
Citations number
5
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF CHROMATOGRAPHY A → ACNP
Volume
829
Issue
1-2
Year of publication
1998
Pages
143 - 152
Database
ISI
SICI code
Abstract
Based on environmental requirements and demands for a high throughput a rap id method for the analysis of nicotine and nicotine-related substances in c hewing gum formulations was developed. The method is based on sample prepar ation through liquid-liquid extraction followed by reversed-phase HPLC usin g gradient elution. It allowed up to nine analytes to be determined within 15 min, including the sample preparation, and was considered as accurate an d robust. (C) 1998 Elsevier Science B.V. All rights reserved.