Measurement of four tumor marker antigens in the sera of pregnant women

Citation
Cd. Cheli et al., Measurement of four tumor marker antigens in the sera of pregnant women, J CL LAB AN, 13(1), 1999, pp. 35-39
Citations number
21
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF CLINICAL LABORATORY ANALYSIS
ISSN journal
08878013 → ACNP
Volume
13
Issue
1
Year of publication
1999
Pages
35 - 39
Database
ISI
SICI code
0887-8013(1999)13:1<35:MOFTMA>2.0.ZU;2-G
Abstract
We sought to determine the maternal serum levels of four tumor-associated a ntigens during the three trimesters of pregnancy in healthy women. CEA, CA 228, CA 15-3, and Her2/neu oncogene product p105 assay values were determin ed for 90 healthy pregnant women during the three trimesters of pregnancy a t five participating evaluation sites. Results were compared to means and c ut-off values determined for healthy nonpregnant women. Differences in assa y values in the 1 st and 3rd trimester were analyzed for statistical signif icance (Student's t-test). CEA, CA 228 and CA 15-3 assay values in general were found to be within the normal range. CA 15-3 and Her2/neu p105 serum a ssay values were above the cut-off (3.3% and 8.2%, respectively) and were s ignificantly elevated in the 3rd trimester as compared to the 1st trimester of pregnancy (P < 0.05 and P < 0.001, respectively). CEA and CA 228 may be of potential value in monitoring pregnant women with malignant disease. No rmal elevations in 3rd trimester serum Her2/neu p105 and CA 15-3 assay valu es should be considered when monitoring a pregnant patient with malignant d isease. (C) 1999 Wiley-Liss, Inc.