A MULTICENTER (DOUBLE-BLIND) COMPARATIVE-STUDY TO ASSESS THE SAFETY AND EFFICACY OF FLUCONAZOLE AND GRISEOFULVIN IN THE TREATMENT OF TINEA-CORPORIS AND TINEA-CRURIS
J. Faergemann et al., A MULTICENTER (DOUBLE-BLIND) COMPARATIVE-STUDY TO ASSESS THE SAFETY AND EFFICACY OF FLUCONAZOLE AND GRISEOFULVIN IN THE TREATMENT OF TINEA-CORPORIS AND TINEA-CRURIS, British journal of dermatology, 136(4), 1997, pp. 575-577
In a double-blind, parallel group study we compared fluconazole 150 mg
once weekly with griseofulvin 500 mg once daily for 4-6 weeks in the
treatment of tinea corporis or tinea cruris, Eighty-four of 114 patien
ts (74%) (39% after 3 weeks) were clinically cured in the fluconazole
group compared with 72 of 116 (62%) (39% after 3 weeks) in the griseof
ulvin group (P = 0.06), In the fluconazole group 78% were mycological
cured compared with 80% in the griseofulvin group, In the fluconazole
group nine patients (7.5%) had treatment related adverse events and in
the griseofulvin group 15 patients (12.5%) had adverse events, Flucon
azole 150 mg once weekly for 6 weeks is both clinically and mycologica
lly effective in the treatment of tinea corporis and tinea cruris and
few side-effects were reported.