New products from the reactions of artemisinin with ammonia and amines

Authors
Galal, AM Ahmad, MS El-Feraly, FS McPhail, AT
Citation
Am. Galal et al., New products from the reactions of artemisinin with ammonia and amines, J NAT PROD, 62(1), 1999, pp. 54-58
Citations number
9
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
1
Year of publication
1999
Pages
54 - 58
Database
ISI
SICI code
0163-3864(199901)62:1<54:NPFTRO>2.0.ZU;2-L
Abstract
Reaction of artemisinin (I) with ammonia, methylamine, dimethylamine, and a llylamine afforded five unexpected products 2-6, in addition to the previou sly reported compounds 7-12. The identities of the new compounds were estab lished from their spectral data, by chemical derivatization and by comparis on with published reports. The stereochemistries of compounds 5 and 6 were confirmed by single-crystal X-ray analysis.