An expeditious procedure for the isolation of ingenol from the seeds of Euphorbia lathyris

Authors
Appendino, G Tron, GC Cravotto, G Palmisano, G Jakupovic, J
Citation
G. Appendino et al., An expeditious procedure for the isolation of ingenol from the seeds of Euphorbia lathyris, J NAT PROD, 62(1), 1999, pp. 76-79
Citations number
26
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
1
Year of publication
1999
Pages
76 - 79
Database
ISI
SICI code
0163-3864(199901)62:1<76:AEPFTI>2.0.ZU;2-X
Abstract
A short and practical process for the isolation of ingenol (la) from an agr icultural commodity (the seeds of Euphorbia lathyris) is described. Macrocy clic diterpene esters are obtained as byproducts, and the esterification pa ttern of the Euphorbia factors L-2 (3), L-3 (4b), and L-8 (4b) was establis hed by 2D NMR measurements. Full spectroscopic data for these compounds are reported.