Loloatins A-D, cyclic decapeptide antibiotics produced in culture by a tropical marine bacterium

Loloatins A (1) to D (4), a family of new cyclic decapeptide antibiotics, h ave been isolated from laboratory cultures of a tropical marine bacterium r ecovered from the Great Barrier Reef in Papua New Guinea. The structures of loloatins A-D were elucidated via a combination of spectroscopic analyses and chemical degradation. Loloatins A-D exhibit in vitro antimicrobial acti vity against methicillin-resistant Staphyloccoccus aureus, vancomycin-resis tant enterococci, and drug-resistant Streptococcus pneumoniae.