Interleukin-1 and tumor necrosis factor antagonists inhibit the progression of inflammatory cell infiltration toward alveolar bone in experimental periodontitis
Dt. Graves et al., Interleukin-1 and tumor necrosis factor antagonists inhibit the progression of inflammatory cell infiltration toward alveolar bone in experimental periodontitis, J PERIODONT, 69(12), 1998, pp. 1419-1425
PERIODONTAL DISEASE IS A SIGNIFICANT cause of tooth loss in humans and is o
ne of the most prevalent diseases associated with bone loss. Following bact
erial colonization, the gingiva becomes inflamed and, in some cases, progre
sses to destruction of alveolar bone. To investigate the temporal movement
of inflammatory cells toward alveolar bone and the role of interleukin-1 (I
L-1) and tumor necrosis factor (TNF) in this process, studies were carried
out in a Macaca fascicularis primate model of experimental periodontitis. I
L-1 and TNF activity was inhibited by local application of soluble receptor
s to IL-1 and TNF by injection into interdental papillae. The results indic
ate that following induction of experimental periodontitis, the front of in
flammatory cells progresses toward alveolar bone and is associated with ost
eoclast formation. These processes are inhibited by blockers to IL-1 and TN
F. These studies suggest that the conversion from gingivitis to periodontit
is is directly associated with the movement of an inflammatory infiltrate t
oward alveolar bone, and that this activity is at least partially dependent
upon IL-1 and/or TNF.