Because there is a large overlap between HIV manifestations and somatic sym
ptoms of anxiety and depression, it is crucial to use measures that do not
contain somatic items to validly and reliably assess these psychological st
ates in HIV-infected patients. The purpose of this study was to assess the
psychometric properties of the Hospital Anxiety and Depression Scale (HADS)
, a questionnaire that does not include any somatic items, in HIV-seroposit
ive individuals. Because the study was conducted among French Canadian indi
viduals, the quality of the translation was Ist subjectively and empiricall
y assessed. Then, the psychometric properties of the HADS were evaluated in
162 HIV-seropositive patients, who, in addition to the HADS, also complete
d the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory
. The French Canadian version used was found to be subjectively and empiric
ally equivalent to the original English version. Moreover, results of this
study demonstrated a bifactorial structure with factors corresponding to th
e HADS subscales, an excellent internal consistency and test-retest reliabi
lity, a very good convergent validity, and an acceptable discriminant valid
ity. Strikingly, in contrast to the BDI, HADS scores were found to be uncon
founded by the presence of HIV symptomatology. The HADS appears to represen
t the best currently available self-report scale to reliably and validly as
sess anxiety and depression in HI;V-infected patients. The HADS is simple a
nd brief to administer (14 items) and may therefore be easily implemented i
n routine HIV care.