Lipid storage myopathy in a cocker spaniel

A six-year-old male cocker spaniel was presented to the Veterinary Medical Teaching Hospital, University of Florida, with a three-week history of gene ralised weakness and myalgia, Electrodiagnostic evaluation, cerebrospinal f luid analysis and thoracolumbar myelography were unremarkable. Biopsies fro m vastus lateralis and triceps muscles revealed numerous large lipid drople ts within type 1 fibres and to a lesser degree within type 2 fibres, The re sting plasma lactate was mildly increased and there was elevated urinary ex cretion of lactic, pyruvic and acetoacetic acids, increased urinary excreti on of carnitine esters, and increased plasma alanine, This pattern of metab olite excretion is consistent with an, as yet undefined, block in oxidative metabolism.