Peak pulse blood volume and topical antiglaucomatous drugs in a cynomolgusmonkey high tension glaucoma model

Background The present study was designed to investigate the effect of topi cal antiglaucoma drugs on Peak Pulse Blood Volume (PPBV; German abreviation : PGBV) in cynomolgus monkey eyes without (CMNG; German abreviation: RA-KTL ) and with lasersurgically induced glaucoma (CMG; German abreviation: RA-LH DG). Methods CMG unilaterally received 2-3 laser treatments so as to develop the lasered-eye glaucoma model. Intraocular pressure (IOP; German abreviation: IOD) and Ocular Pulse Amplitude were measured and PPBV was determined unti l the glaucoma model had stabilized. Consecutively topical antiglaucoma dru gs (epinephrine, paraaminoclonidine, pilocarpine, timolol) were investigate d in 4-8 animals in CMNG and CMG eyes. Results SOP and PPBV were not significantly altered in CMNG. In the CMG eye s epinephrine and paraaminoclonidine did not significantly alter IOP or PPB V, whereas pilocarpine and timolol sig. (p<0.01) reduced IOP and significan tly (p < 0.05) increased PPBV. Conclusion With respect to improved PPBV in the CMG eye the rank order of drug effectiveness is timolol > pilocarpine > paraaminoclonidine > epinephrine.