Cancer-associated retinopathy in a patient with non-small-cell lung carcinoma

Cancer-associated retinopathy (CAR) is a paraneoplastic syndrome most often associated with small-cell lung carcinoma (SCLC), and it has been reported in patients with other malignancies. Antibodies against recoverin, a 23-kD a protein, have been found in patients with CAR suggesting an autoimmune ph enomenon. Herein is the first report of a patient with non-small-cell lung cancer (NSCLC) in whom anti-recoverin antibodies were detected in the serum . Steroid therapy, chemotherapy, and radiation therapy did not help the pat ient's vision. Progressive loss of vision in patients with lung cancer shou ld, potentially, be tested for CAR. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.