EOSINOPHILIC ANGIOCENTRIC FIBROSIS OF THE NASAL CAVITY

Eosinophilic angiocentric fibrosis (EAF) is a rare condition of unknow n etiology that causes stenosis of the upper respiratory tract, We rep ort one case in which immunohistochemical studies were performed that involved the mucosa of the lateral nasal wall and septum of a 54-year- old woman, The lesion showed areas with vascular proliferation, small- vessel vasculitis, and dense inflammatory infiltrate consisting of T l ymphocytes, macrophages, polyclonal plasma cells, and numerous eosinop hils and neutrophils, Other areas were hypocellular and fibrotic, and in those, the collagen bundles showed perivascular onion-skin whorling , The clinical and histologic similarities between our case and those previously described, in addition to the immunohistochemical findings, support the hypothesis that eosinophilic angiocentric fibrosis is a c hronic inflammatory condition with a peculiar and striking stromal res ponse.