Acute renal failure in allogeneic transplantation of hematopoietic progenitors. Clinical characteristics in a series of 92 patients.

BACKGROUND: Analysis of clinical characteristics of acute renal failure (AR F) after allogeneic bone marrow transplantation (BMT). PATIENTS AND METHODS: Analysis of 92 patients who developed ARF of 260 pati ents following BMT. RESULTS: ARF incidence was 35.4%. Sixty three percent of ARF occurred befor e day 20 after BMT. Duration of ARF was less of 10 days in 72.8%. ARF was n on oliguric in the 80.4% of cases. Most common ARF etiologies were: multifa ctorial (37%), nephrotoxicity (NPH) (33.7%) and venoclusive disease of the liver (VOD) (14.1%). ARF secondary to VOD was the most severe: and the long est, where the secundary to NPH was less lever and shorter. Hemodialysis (H D) was necessary in 22.8% of ARF. Mortality in ARF group was 45.6%, higher in He group (80.9%) than in non-HD group (35.2%) (p<0.0002). CONCLUSIONS: ARF is a frequent complication following BMT. It occurs early, has short duration, is non oliguric, mainly hemodynamic and carries a wors e prognosis.