Rb. Ashman et al., A second Candida albicans resistance gene (Carg2) regulates tissue damage,but not fungal clearance, in sub-lethal murine systemic infection, MICROB PATH, 25(6), 1998, pp. 349-352
The severity of systemic infection with the yeast Candida albicans has been
shown to be under complex genetic control. C57/L mice carry an allele that
is associated with an increase in tissue destruction when compared with C5
7BI/6 mice; however, the gene affects only the severity of tissue lesions,
and does not influence the magnitude of the fungal burden in either kidney
or brain. Studies in [C57/L x C57BI/6]F1 hybrid mice, and [C57/L x C57BI/6]
F1 x C57/L backcross mice, demonstrated that the gene behaves as a simple M
endelian co-dominant. (C) 1998 Academic Press.