The renin-angiotensin system in diabetic nephropathy: The endothelial connection

Authors
Rabelink, TJ Bakris, GL
Citation
Tj. Rabelink et Gl. Bakris, The renin-angiotensin system in diabetic nephropathy: The endothelial connection, MIN ELECT M, 24(6), 1998, pp. 381-388
Citations number
122
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
MINERAL AND ELECTROLYTE METABOLISM
ISSN journal
03780392 → ACNP
Volume
24
Issue
6
Year of publication
1998
Pages
381 - 388
Database
ISI
SICI code
0378-0392(199811/12)24:6<381:TRSIDN>2.0.ZU;2-6
Abstract
In recent years endothelial function has been forwarded a modulator in the pathogenesis of diabetic nephropathy. This review summarizes how an imbalan ce between endothelium-derived reactive nitrogen species and reactive oxyge n species as ell as increased expression of the endotheliumderived peptide endothelin-1 may contribute to loss of renal function in diabetes. In addit ion, the potentially beneficial effects of blockade of the renin-angiotensi n system on this endothelial dysbalance is discussed.