The role of ErbB receptor signaling in cell fate decisions by cortical progenitors: Evidence for a biased, lineage-based responsiveness to different ligands

Citation
Kl. Eagleson et al., The role of ErbB receptor signaling in cell fate decisions by cortical progenitors: Evidence for a biased, lineage-based responsiveness to different ligands, MOL CELL NE, 12(6), 1998, pp. 349-362
Citations number
62
Categorie Soggetti
Neurosciences & Behavoir
Journal title
MOLECULAR AND CELLULAR NEUROSCIENCE
ISSN journal
10447431 → ACNP
Volume
12
Issue
6
Year of publication
1998
Pages
349 - 362
Database
ISI
SICI code
1044-7431(199812)12:6<349:TROERS>2.0.ZU;2-U
Abstract
We recently identified the required collaborative signaling of TGF alpha an d collagen type IV to regulate cell fate choice in the cerebral cortex, mea sured by the expression of the limbic system associated membrane protein (L AMP) by nonlimbic, sensorimotor progenitors. We show that activation of dif ferent members of the erbB receptor family can similarly modulate the speci fication of cortical area fate. The region of the cerebral wall from which progenitor cells arise does not Influence the response to the neuregulin-1 or TGF alpha, but a subpopulation of progenitors is not competent to expres s LAMP in response to neuregulin-1. The heterogeneity in the responsiveness by progenitors to the two growth factors is reflected in the expression of different repertoires of erbB receptors. Using clonal analysis, we demonst rate that there may be a lineage-dependent mechanism regulating the ability of neuronal progenitors to respond to specific inductive cues that control cell fate.