Molecular cloning of human GABA(B)R1 and its tissue distribution

Authors
Makoff, A
Citation
A. Makoff, Molecular cloning of human GABA(B)R1 and its tissue distribution, MOL BRAIN R, 64(1), 1999, pp. 137-140
Citations number
11
Categorie Soggetti
Neurosciences & Behavoir
Journal title
MOLECULAR BRAIN RESEARCH
ISSN journal
0169328X → ACNP
Volume
64
Issue
1
Year of publication
1999
Pages
137 - 140
Database
ISI
SICI code
0169-328X(19990122)64:1<137:MCOHGA>2.0.ZU;2-0
Abstract
GABA(B)R1 clones were isolated from a human cerebellum library. The human s equence is very similar to rat GABA(B)R1 with the cDNAs sharing 91.3% seque nce identity and the receptors sharing 98.6% amino acid sequence identity. Northern blotting has shown that the receptor is brain-specific with a wide spread distribution throughout the brain but none detected in the spinal co rd. (C) 1999 Elsevier Science B.V. All rights reserved.