Recombination with host transgenes and effects on virus evolution: An overview and opinion

Citation
T. Rubio et al., Recombination with host transgenes and effects on virus evolution: An overview and opinion, MOL PL MICR, 12(2), 1999, pp. 87-92
Citations number
74
Categorie Soggetti
Plant Sciences","Animal & Plant Sciences
Journal title
MOLECULAR PLANT-MICROBE INTERACTIONS
ISSN journal
08940282 → ACNP
Volume
12
Issue
2
Year of publication
1999
Pages
87 - 92
Database
ISI
SICI code
0894-0282(199902)12:2<87:RWHTAE>2.0.ZU;2-1
Abstract
This commentary relates to the work by M. Borja et al, (M. Borja, T. Rubio, H. B. Scholthof, and A. O. Jackson, MPMI 12:153-162, 1999) that shows that wild-type virus can be restored frequently by double recombination events between a tomato bushy stunt virus mutant with deletions inactivating the c oat protein gene and a coat protein transgene. Here, we focus on evidence s uggesting that new viruses might evolve via recombination with transgenes u sed for disease resistance, and discuss the potential effects of widespread use of these sources of resistance on virus evolution. We argue that the b enefits arising from using transgenic sources of resistance for virus disea se control outweigh potential negative consequences of evolution of novel h ybrid viruses with destructive disease potential.