M. Foksinski et al., Evaluation of 8-oxodeoxyguanosine, typical oxidative DNA damage, in lymphocytes of ozone-treated arteriosclerotic patients, MUT RES-GTE, 438(1), 1999, pp. 23-27
Citations number
30
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
In the present study we measured the amount of 8-oxo-2'-deoxyguanosine (8-o
xo-dG) in DNA isolated from lymphocytes of arteriosclerotic patients underg
oing ozonetherapy. Treatment of the patients with therapeutic concentration
of ozone caused a significant increase over the control value in the amoun
t of 8-oxo-dG of DNA isolated from their lymphocytes. However, only three o
ut of six patients examined responded positively to the treatment in terms
of the base damage. The increases varied among patients, and were in the ra
nge of 100-450%. This interindividual difference may at least be partly exp
lained by recently demonstrated heritable susceptibility to ozone. (C) 1999
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