Use of mitomycin C in repeat dacryocystorhinostomy

Purpose: The usefulness of a single intraoperative application of mitomycin C was investigated in repeat dacryocystorhinostomy for membranous failure. Methods: Mitomycin C (0.3 mg/ml for 3 minutes) was topically applied to the fistula site in eight patients undergoing repeat dacryocystorhinostomy for membranous failure. Results: All patients remain asymptomatic and anatomic patency confirmed by probe and irrigation with a mean follow-up period of 14.6 months (range, 6 -26 months). No postoperative complications associated with the use of mito mycin C were observed. Conclusions: In patients who do not maintain a patent fistula after dacryoc ystorhinostomy because of membranous occlusion of the rhinostomy site, the adjunctive use of mitomycin C may increase the success rate of repeat dacry ocystorhinostomy.