Cerebrolysin ameliorates performance deficits, and neuronal damage in apolipoprotein E-deficient mice

Recent studies suggest that Cerebrolysin improves behavioral performance by affecting synaptic transmission in the hippocampus. The main objective of this study was to determine if Cerebrolysin administration ameliorates the neurodegenerative and performance deficits in aged apolipoprotein E (apoE)- deficient mice. ApoE-deficient mice treated with Cerebrolysin showed a sign ificant improved performance in the Morris water maze, compared to saline-t reated apoE-deficient mice. Although the improved performance in the Cerebr olysin-treated apoE-deficient mice was associated with restoration of the n euronal structure, the poor learning ability of saline-treated apoE-deficie nt mice was related to the a disrupted synaptodendritic structure. This stu dy supports the contention that Cerebrolysin might have a neurotrophic effe ct in vivo. (C) 1999 Elsevier Science Inc.