Stress and a glycinergic intervention interact in the modulation of MK-801-elicited mouse popping behavior

The ability of D-cycloserine, a partial glycine agonist, to modulate mouse popping behavior elicited by MK-801, a noncompetitive NMDA receptor antagon ist, was studied in unstressed and stressed mice. In unstressed animals, D- cycloserine (5.6 and 10 mg/kg) attenuated the ability of MK-801 (1.0 mg/kg) to elicit this behavior. However, the ability of D-cycloserine to attenuat e MK-801-elicited mouse-popping behavior was not evident in stressed mice, 24 h after they were forced to swim for up to 10 min in cold water. Thus, t he therapeutic value of glycinergic interventions may be limited by environ mental factors, such as stress. (C) 1999 Elsevier Science Inc.