From the root heart wood of Tectona grandis were isolated a new compound, 5
-hydroxylapachol (1) along with the known constituents lapachol, dehydro-al
pha-lapachone, methylquinizarin and squalene. Both compound 1 and lapachol
were found to be cytotoxic to Artemia salina (brine shrimp) with an LC50 of
5 ppm. The structure of compound 1 has been elucidated on the basis of its
spectral data, mainly, H-1 and C-13 NMR. (C) 1998 Published by Elsevier Sc
ience Ltd. All rights reserved.