5-hydroxylapachol: A cytotoxic agent from Tectona grandis

Authors
Khan, RM Mlungwana, SM
Citation
Rm. Khan et Sm. Mlungwana, 5-hydroxylapachol: A cytotoxic agent from Tectona grandis, PHYTOCHEM, 50(3), 1999, pp. 439-442
Citations number
21
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
50
Issue
3
Year of publication
1999
Pages
439 - 442
Database
ISI
SICI code
0031-9422(199902)50:3<439:5ACAFT>2.0.ZU;2-R
Abstract
From the root heart wood of Tectona grandis were isolated a new compound, 5 -hydroxylapachol (1) along with the known constituents lapachol, dehydro-al pha-lapachone, methylquinizarin and squalene. Both compound 1 and lapachol were found to be cytotoxic to Artemia salina (brine shrimp) with an LC50 of 5 ppm. The structure of compound 1 has been elucidated on the basis of its spectral data, mainly, H-1 and C-13 NMR. (C) 1998 Published by Elsevier Sc ience Ltd. All rights reserved.