Cryptic plasmids pDP1 and pSMB1 from clinical strains of Streptococcus pneu
moniae isolated 74 years apart were found to be essentially identical in th
eir nucleotide sequence. pDP1, 3161 bp, contains live codirectional ORFs an
d presents all the general features of plasmids replicating by the rolling
circle mechanism. The rep gene, 963 bp, is highly homologous to the rep gen
e of other streptococcal plasmids of the pC194 family. (C) 1999 Academic Pr
ess.