Two cases of Gushing's disease are presented. In both cases successful trea
tment was followed by the development of a steroid-responsive disease condi
tion,a seronegative arthritis in the first case and retinal vasculitis in t
he second. It is likely that both these conditions were unmasked! by the fa
ll in the endogenous steroid levels following the successful treatment of t
he Cushing's disease by trans-sphenoidal hypophysectomy.