J. Tacke et al., An experimental model of early-chronic iliac vein thrombosis with occlusion coils and thrombin., ROFO-F RONT, 169(6), 1998, pp. 645-648
Citations number
12
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging
Journal title
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
Purpose: To create an early chronic venous thrombosis with good comparabili
ty to human venous thrombosis for evaluation of new thrombectomy systems. M
ethods: Using a transjugular approach, three dacron-fibered occlusion coils
were placed into the proximal common iliac vein of 7 pigs under general an
esthesia. The coiled common iliac vein was blocked by the use of a balloon
occlusion catheter, and 500 units of thrombin were injected into the "coil
basket". One hour later, the ballon catheter was deflated and removed. Afte
r three days, the thrombus was controlled by phlebography and histology. Re
sults: The induction of thrombi was successful in all cases. The mean lengt
h of the thrombi was 60 mm and the mean diameter was 10 mm. Histologically,
the thrombus consisted of a laminated plug of fibrin and platelets as well
as clots in the sense of a mixed thrombus with signs of a beginning organi
zation. Considering the cellular composition and the histological aspect, t
he thrombi met the criteria for early chronic venous thrombosis in humans.
Conclusion: The presented experimental thrombus model is easy to perform an
d enables a good comparability to early chronic human venous thrombosis.