Discrete-event simulation models of Plasmodium falciparum malaria

We develop discrete-event simulation models using a single "timeline" varia ble to represent the Plasmodium falciparum lifecycle in individual hosts an d vectors within interacting host and vector populations. Where they are co mparable, our conclusions regarding the relative importance of vector morta lity and the durations of host immunity and parasite development are congru ent with those of classic differential-equation models of malaria epidemiol ogy. However, our results also imply that in regions with intense perennial transmission, the influence of mosquito mortality on malaria prevalence in humans may be rivaled by that of the duration of host infectivity.