Successful treatment of widely disseminated acanthamoebiasis

Disseminated Acanthamoeba infections are almost invariably fatal, with no u niversally accepted standard for treatment. Reports of acanthamoebiasis in non-human-immunodeficiency-virus infected hosts are rare. We successfully t reated a lung transplant patient who had disseminated acanthamoebiasis usin g a combination of pentamidine, 5-fluorocytosine, itraconazole, and topical chlorhexidine gluconate/ketoconazole cream.