Ds. Bose et V. Lakshminarayana, Lewis acid-mediated selective removal of N-tert-butoxycarbonyl protective group (t-Boc), SYNTHESIS-S, (1), 1999, pp. 66-68
A simple and efficient method for the selective cleavage of N-Boc protectiv
e groups from amines employing Lewis acid aluminum chloride, is described.
The scope of this procedure is explored for the deprotection of a variety o
f amines including amino acid derivatives.