Cyclic peptides from higher plants. Part 45 - Cyclolinopeptides B-E, new cyclic peptides from Linum usitatissimum

Authors
Morita, H Shishido, A Matsumoto, T Itokawa, H Takeya, K
Citation
H. Morita et al., Cyclic peptides from higher plants. Part 45 - Cyclolinopeptides B-E, new cyclic peptides from Linum usitatissimum, TETRAHEDRON, 55(4), 1999, pp. 967-976
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
4
Year of publication
1999
Pages
967 - 976
Database
ISI
SICI code
0040-4020(19990122)55:4<967:CPFHPP>2.0.ZU;2-R
Abstract
New cyclic nona and octapeptides, cyclolinopeptides B - E were isolated fro m the seeds of Linum usitatissimum and their structures were elucidated as cyclo (-Pro-Pro-Phe-Phe-Val-Ile-Met-Leu-Ile-), cyclo (-Pro-Pro-Phe-Phe-VaI- Ile-Mso-Leu-Ile-), cycle (-Pro-Phe-Wle-Trp-Ile-Mso-Leu-Leu-), and cyclo (-P ro-Leu-Phe-Ile-Mso-Leu-Val-Phe-), respectively, by extensive 2D NMR methods and chemical degradations. Cyclolinopeptides B and E showed immunosuppress ive activity. (C) 1999 Elsevier Science Ltd. All rights reserved.