Straightforward synthesis of N-protected benzylic amines by carbamoalkylation of aromatic compounds

Authors
Bensel, N Pevere, V Desmurs, JR Wagner, A Mioskowski, C
Citation
N. Bensel et al., Straightforward synthesis of N-protected benzylic amines by carbamoalkylation of aromatic compounds, TETRAHEDR L, 40(5), 1999, pp. 879-882
Citations number
5
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
5
Year of publication
1999
Pages
879 - 882
Database
ISI
SICI code
0040-4039(19990129)40:5<879:SSONBA>2.0.ZU;2-4
Abstract
A wide range of alkoxycarbonyl protected benzylic amines have been synthesi zed in a three component reaction involving a carbamate an aldehyde and an aromatic substrate, This reaction proceeds through electrophilic substituti on of the aromatic compound by a N-carbamoyl iminium which is generated in situ by condensation of the carbamate with the aldehyde. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.