A highly effective phosphinite ligand derived from D-mannitol for Rh-catalyzed asymmetric hydrogenation

Authors
Chen, YX Li, XS Tong, SK Choi, MCK Chan, ASC
Citation
Yx. Chen et al., A highly effective phosphinite ligand derived from D-mannitol for Rh-catalyzed asymmetric hydrogenation, TETRAHEDR L, 40(5), 1999, pp. 957-960
Citations number
7
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
5
Year of publication
1999
Pages
957 - 960
Database
ISI
SICI code
0040-4039(19990129)40:5<957:AHEPLD>2.0.ZU;2-A
Abstract
A novel chiral phosphinite 1,2, 5,6-di-isopropylidene-3,4-bis(diphenylphosp hino)-D-mannitol was prepared and its rhodium complex was found to be an ef fective catalyst for the asymmetric hydrogenation of amidoacrylic acid and its derivatives with product ee's ranging from 90% to 97%. (C) 1999 Elsevie r Science Ltd. All rights reserved.