The synthesis of asimilobin and the correction of its tetrahydrofuran segment's configuration

Authors
Wang, ZM Tian, SK Shi, M
Citation
Zm. Wang et al., The synthesis of asimilobin and the correction of its tetrahydrofuran segment's configuration, TETRAHEDR L, 40(5), 1999, pp. 977-980
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
5
Year of publication
1999
Pages
977 - 980
Database
ISI
SICI code
0040-4039(19990129)40:5<977:TSOAAT>2.0.ZU;2-O
Abstract
A highly efficient synthetic method for the trans/threo/trans- bis-tetrahyd rofuran (THF) ring building block was established. The title compound was s ynthesized in thirteen steps from trans-1,4-dichloro-2-butene via a converg ent route with a Wittig reaction as the key step. The absolute configuratio n of the THF segment of naturally occurring asimilobin should be corrected. (C) 1999 Elsevier Science Ltd. All rights reserved.