A decarboxylative traceless linker approach for the solid phase synthesis of quinazolines

Authors
Cobb, JM Fiorini, MT Goddard, CR Theoclitou, ME Abell, C
Citation
Jm. Cobb et al., A decarboxylative traceless linker approach for the solid phase synthesis of quinazolines, TETRAHEDR L, 40(5), 1999, pp. 1045-1048
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
5
Year of publication
1999
Pages
1045 - 1048
Database
ISI
SICI code
0040-4039(19990129)40:5<1045:ADTLAF>2.0.ZU;2-E
Abstract
A decarboxylative traceless linker strategy for the cleavage of resin-bound quinazolines has been developed using hydroxymethylpolystyrene (HMPS) resi n derivatised as the ethyl oxalate. Methods for the solid phase synthesis o f the linker, quinazoline formation, functionalisation and cleavage are des cribed. (C) 1999 Elsevier Science Ltd. All rights reserved.