Human atheromatous plaque extracts induce tissue factor activity (TFa) in monocytes and also express constitutive TFa

Citation
Tw. Muhlfelder et al., Human atheromatous plaque extracts induce tissue factor activity (TFa) in monocytes and also express constitutive TFa, THROMB HAEM, 81(1), 1999, pp. 146-150
Citations number
38
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
THROMBOSIS AND HAEMOSTASIS
ISSN journal
03406245 → ACNP
Volume
81
Issue
1
Year of publication
1999
Pages
146 - 150
Database
ISI
SICI code
0340-6245(199901)81:1<146:HAPEIT>2.0.ZU;2-H
Abstract
Tissue factor activity (TFa) is a major activator of the coagulation cascad e and may play a role in atheroma-induced thrombosis. Monocyte-macrophages (MO-MF) generate considerable quantities of TFa when stimulated by a variet y of inducers. To test the hypothesis that MO could be induced by atheromat ous plaque to generate TFa, plaque extracts obtained from patients with obs tructive atheromatous disease were used. These extracts were also assayed f or constitutive TFa. The constitutive activity was variable from extract to extract but could be very high, up to 250 U TFa. The TFa induced in MO cou ld be also very high. up to 200 U (i.e, 1/5 of the TFa of full strength rab bit brain thromboplastin). These findings point to a major role for MO-MF T Fa in the induction or thrombosis by atheromatous plaque.