Orthotopic liver transplantation can be performed successfully in thalassem
ia. In this article, we describe a case of liver transplantation in a patie
nt with sickle cell/beta-thalassemia complicated by liver sickling. Intrahe
patic sickling must be considered in case of allograft dysfunction. This co
ndition can easily be diagnosed by biochemical investigation and liver ultr
asonography.