Canine cystine urolithiasis - Cause, detection, treatment, and prevention

Cystine uroliths are a sequela to cystinuria, an inherited renal tubular de fect in reabsorption of cystine and some other amino acids. At the Minnesot a Urolith Center, 67 breeds of dogs were identified, including English Bull dogs, Dachshunds, Mastiffs, and Newfoundlands. In some dogs, the severity o f cystinuria may decline with advancing age. Current recommendations for di ssolution of cystine uroliths include various combinations of diet modifica tion, diuresis, administration of 2-MPG, and alkalinization of urine.