Drug-induced urolithiasis

Authors
Osborne, CA Lulich, JP Bartges, JW Ulrich, LK Koehler, LA Bird, KA Swanson, LL Austin, GW Prien, EL Steinam, KU
Citation
Ca. Osborne et al., Drug-induced urolithiasis, VET CLIN SM, 29(1), 1999, pp. 251
Citations number
17
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
ISSN journal
01955616 → ACNP
Volume
29
Issue
1
Year of publication
1999
Database
ISI
SICI code
0195-5616(199901)29:1<251:DU>2.0.ZU;2-Q
Abstract
Diagnostic and therapeutic drugs may enhance urolithiasis in one or a combi nation of ways, including: (1) alteration of urine pH in such fashion as to create an environment that increases the solubility of some lithogenic sub stances, (2) alteration of glomerular filtration rate, tub;lar reabsorption , and tubular secretion of drugs of endogenous substances so as to enhance promoters or impair inhibitors of urolithiasis, and (3) precipitation (e.g. , drugs or their metabolites) to form a portion or all of a urolith.