Clinical use of a topical carbonic anhydrase inhibitor in patients affected by chronic simple glaucoma

A cross-over double-blind study was performed to evaluate the effect of acu te administration of brimonidine on the blue-yellow perimetry. Thirty patie nts with primary open-angle glaucoma were admitted. After brimonidine admin istration, IOP and pupil diameter showed a significant reduction (p<0.01) w ithout modification in systolic and diastolic blood pressure. Blue-on-yello w perimetry showed a significant reduction in CPSD from 3.81+/-1.60 to 2.71 +/-1.92 (p<0.05). This result suggests that brimonidine improves ocular per fusion via a reduction of IOP.