PROFILES OF VOLTAGE AND OF CHANNEL DENSITY IN A PLANAR MEMBRANE CABLEON MICROMACHINED SILICON

Authors
KLINGLER J FROMHERZ P
Citation
J. Klingler et P. Fromherz, PROFILES OF VOLTAGE AND OF CHANNEL DENSITY IN A PLANAR MEMBRANE CABLEON MICROMACHINED SILICON, Berichte der Bunsengesellschaft fur Physikalische Chemie, 99(7), 1995, pp. 958-964
Citations number
22
Categorie Soggetti
Chemistry Physical
Journal title
Berichte der Bunsengesellschaft fur Physikalische Chemie
ISSN journal
00059021 → ACNP
Volume
99
Issue
7
Year of publication
1995
Pages
958 - 964
Database
ISI
SICI code
0005-9021(1995)99:7<958:POVAOC>2.0.ZU;2-4
Abstract
A lipid bilayer of glycerolmonoleate is spanned over a microscopic sha llow groove etched into the 110 surface of a silicon wafer and insulat ed by thermal oxidation. The conductance of the bimolecular membrane i s modulated by gramicidin. The voltage profile in the groove is record ed by a set of Ag/AgCl electrodes which are integrated into the bottom of the groove. It is used to determine the distribution of ion channe ls along the membrane on the basis of Kelvin's cable equation.