Evidence for protein splicing in the endoplasmic reticulum-Golgi intermediate compartment

Authors
Demirov, D Sarafian, V Kremensky, I Ganev, V
Citation
D. Demirov et al., Evidence for protein splicing in the endoplasmic reticulum-Golgi intermediate compartment, BBA-MOL CEL, 1448(3), 1999, pp. 507-511
Citations number
13
Categorie Soggetti
Cell & Developmental Biology
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
ISSN journal
01674889 → ACNP
Volume
1448
Issue
3
Year of publication
1999
Pages
507 - 511
Database
ISI
SICI code
0167-4889(19990111)1448:3<507:EFPSIT>2.0.ZU;2-3
Abstract
We present evidence that the endoplasmic reticulum-Golgi intermediate compa rtment (ERGIC) is a site for protein splicing of cathepsin C: (i) maturatio n of the enzyme in COS 7 cells is a two-step process starting within the ER GIC, and (ii) the intermediately processed polypeptide retains both termini of the proenzyme and lacks an internal fragment. (C) 1999 Elsevier Science B.V. All rights reserved.