Slow excitation waves and mechanisms of polymorphic ventricular tachycardia in the experimental model: Isolated walls of rabbit and ground squirrel right ventricle
Ni. Kukushkin et al., Slow excitation waves and mechanisms of polymorphic ventricular tachycardia in the experimental model: Isolated walls of rabbit and ground squirrel right ventricle, BIOFIZIKA, 43(6), 1998, pp. 1043-1059
The mechanism of polymorphic disturbances of the heart rhythm is studied on
an experimental model, isolated ventricular preparations of ground squirre
l and rabbit. Polymorphic arrhythmias are identified from habitus of the is
olated preparation pseudoECGs mathematically derived from electrograms regi
stered simultaneously at 32 endocardial and 32 epicardial points. The same
electrograms allow one to visualize the excitation wave propagation along e
ach of the preparation surfaces. The comparison of excitation wave pictures
and corresponding pseudoECGs enabled us to reveal the conditions necessary
and sufficient for polymorphism in heart rhythm disturbances. Polymorphic
arrhythmias are due to changes in wave pictures in the regions of retarded
excitation propagation.