Substituted heterocyclic analogs as selective COX-2 inhibitors in the Flosulide class

Authors
Ouimet, N Chan, CC Charleson, S Claveau, D Gordon, R Guay, D Li, CS Ouellet, M Percival, DM Riendeau, D Wong, E Zamboni, R Prasit, P
Citation
N. Ouimet et al., Substituted heterocyclic analogs as selective COX-2 inhibitors in the Flosulide class, BIOORG MED, 9(2), 1999, pp. 151-156
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
2
Year of publication
1999
Pages
151 - 156
Database
ISI
SICI code
0960-894X(19990118)9:2<151:SHAASC>2.0.ZU;2-1
Abstract
Substituted heterocyclic analogs in the Flosulide class were investigated a s potential selective . 6-(4-Ethyl-2-thiazolylthio)-5-methanesulfonamido-3H -isobenzofuran-1-one 14 was found to be the optimal compound in the series with superior in vitro and in vivo activities. (C) 1999 Elsevier Science Lt d. All rights reserved.