A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases

Authors
Mazzucco, S Mata, S Vergelli, M Fioresi, R Nardi, E Mazzanti, B Chelli, M Lolli, F Ginanneschi, D Pinto, F Massacesi, L Papini, AM
Citation
S. Mazzucco et al., A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases, BIOORG MED, 9(2), 1999, pp. 167-172
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
2
Year of publication
1999
Pages
167 - 172
Database
ISI
SICI code
0960-894X(19990118)9:2<167:ASGOHM>2.0.ZU;2-L
Abstract
Glycopeptides of hMOG(30-50) containing a glucosyl moiety on the side-chain s of Asn, Ser or Hyp at position 31 were synthesised. Antibody titres to hM OG(30-50) and to its glucoderivatives were measured by ELISA in sera of pat ients affected by different neurological diseases. Anti-hMOG(30-50) antibod ies were detected only using the glycopeptide [Asn(31)(N-Glc)]hMOG(30-50). (C) 1999 Elsevier Science Ltd. All rights reserved.