Synthesis of an imidazo[1,2-e]purine-acridine heterodimer for targeting abasic sites in DNA

Authors
Belmont, P Alarcon, K Demeunynck, M Lhomme, J
Citation
P. Belmont et al., Synthesis of an imidazo[1,2-e]purine-acridine heterodimer for targeting abasic sites in DNA, BIOORG MED, 9(2), 1999, pp. 233-236
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
2
Year of publication
1999
Pages
233 - 236
Database
ISI
SICI code
0960-894X(19990118)9:2<233:SOAIHF>2.0.ZU;2-Z
Abstract
Cyclization of 8-bromo-9-alkylaminoethyl-adenine quantitatively affords a s ubstituted imidazo[1,2-e]purine. The corresponding heterodimer, imidazo[1,2 -e]purine-acridine, was prepared and its interaction with abasic site conta ining oligonucleotides was studied. (C) 1999 Elsevier Science Ltd. All righ ts reserved.