N-Phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists.

Authors
Auberson, YP Acklin, P Bischoff, S Moretti, R Ofner, S Schmutz, M Veenstra, SJ
Citation
Yp. Auberson et al., N-Phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists., BIOORG MED, 9(2), 1999, pp. 249-254
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
2
Year of publication
1999
Pages
249 - 254
Database
ISI
SICI code
0960-894X(19990118)9:2<249:NIVAAA>2.0.ZU;2-0
Abstract
N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphon ic acids yield potent and selective AMPA and/or NMDA (glycine-binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble an d display potent anticonvulsant effects in the electroshock-induced convuls ion assay in mice. (C) 1999 Elsevier Science Ltd. All rights reserved.