Jt. Kley et al., Synthesis and PLA(2)-inhibitory properties of 2(R)-acetamidoalkylphosphomethanols with a variable aggregate anchor, BIOORG MED, 9(2), 1999, pp. 261-264
Acylamino inhibitors of 14 kDa-PLA(2) were synthesized which differ in the
moiety that is not bound into the enzyme's active site but immersed in the
lipid aggregate when a ternary inhibitory complex is formed. Our results in
dicate that this part of the inhibitors does not significantly influence in
hibitory properties as long the amphiphilic character is retained. So, inhi
bitory and biophysical properties should be variable independently. (C) 199
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